Nov 27 2023

Hybrid Biopolymer Transistors – Implications for Brain Machine Interface

There are several technologies which seem likely to be transformative in the coming decades. Genetic bioengineering gives us the ability to control the basic machinery of life, including ourselves. Artificial intelligence is a suite of active, learning, information tools. Robotics continues its steady advance, and is increasingly reaching into the micro-scale. The world is becoming more and more digital, based upon information, and our ability to translate that information into physical reality is also increasing.

Finally, we are increasingly able to interface ourselves with this digital technology, through brain machine interfaces, and hybrid biological technology. This is the piece I want to discuss today, because of a recent paper detailing a hybrid biopolymer transistor. This is one of the goals of computer technology going forward – to make biological, or at least biocompatible, computers. The more biocompatible our digital technology, the better we will be able to interface that technology with biology, especially the human brain.

This begins with the transistor, the centerpiece of modern computing technology. A transistor is basically a switch that has two states, which can be used to store binary information (1s and 0s). If the switch in on, current flows through the semiconductor, and that indicates a 1, if it is off, current does not flow, indicating a zero. The switch is also controlled by a gate separated by an insulator. These switches can turn on and off 100 billion times a second. Circuits of these switches are designed to process information – to do the operations that form the basis of computing. (This is an oversimplification, but this is the basic idea.)\

This new hybrid transistor uses silk proteins as the insulator around the gates of the transistor. The innovation is the ability to control these proteins at the nano-scale necessary to make a modern transistor. Using silk proteins rather than an inorganic substance allows the transistor to react to its environment in a way that purely inorganic transistors cannot. For example, the ambient moisture will affect the insulating properties of these proteins, changing the operation of the gates.

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Nov 20 2023

Hunger Circuitry

One of the organizing principles that govern living organisms is homeostasis. This is a key feature of being alive – maintaining homeostatic equilibrium both internally and externally. Homeostatic systems usually involve multiple feedback loops that maintain some physiological parameter within an acceptable range. For example, our bodies maintain a very narrow temperature range, our blood has a very narrow range for pH, salt content, CO2 concentration, oxygen levels, and many other parameters. Each cell maintains specific concentrations of many electrolytes across their membranes. Organisms maintain the proper amount of total fluid – too much and their tissue becomes edematous and the heart is overworked, too little and they cannot maintain blood pressure or tissue function.

Some of these homeostatic feedback loops are purely physiological, happening at a cellular, tissue, or organ level. You don’t have to think about the pH of your blood. It can manage itself. But many involve behavior as part of the homeostatic system. If you are dehydrated you get thirsty and seek out water. If you are cold you bundle up and seek warmth. If your body requires nutrients you get hungry and eat.

That last one, hunger and eating, turns out to be very tricky. First, this is mostly a behaviorally driven homeostatic system – how much do we eat, what do we eat, when do we eat, and how physically active are we (combined with many metabolic factors). Second, this behavioral homeostatic system is very context dependent. The system anticipates future needs and future conditions, not just our body’s needs in the moment. It also appears that behavior driven by a homeostatic imperative can be extremely powerful. Think about how motivated you get to find water when you are extremely thirsty.

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Nov 16 2023

Trust in Science

How much does the public trust in science and scientists? Well, there’s some good news and some bad news. Let’s start with the bad news – a recent Pew survey finds that trust in scientist has been in decline for the last few years. From its recent peak in 2019, those who answered that science has a mostly positive effect on society decreased from 73% to 57%. Those who say it has a mostly negative effect increased from 3 to 8%. Those who trust in scientists a fair amount or a great deal decreased from 86 to 73%. Those who think that scientific investments are worthwhile remain strong at 78%.

The good news is that these numbers are relatively high compared to other institutions and professions. Science and scientists still remain among the most respected professions, behind the military, teachers, and medical doctors, and way above journalists, clergy, business executives, and lawyers. So overall a majority of Americans feel that science and scientists are trustworthy, valuable, and a worthwhile investment.

But we need to pay attention to early warning signs that this respect may be in jeopardy. If we get to the point that a majority of the public do not feel that investment in research is worthwhile, or that the findings of science can be trusted, that is a recipe for disaster. In the modern world, such a society is likely not sustainable, certainly not as a stable democracy and economic leader. It’s worthwhile, therefore, to dig deeper on what might be behind the recent dip in numbers.

It’s worth pointing out some caveats. Surveys are always tricky, and the results depend heavily on how questions are asked. For example, if you ask people if they trust “doctors” in the abstract the number is typically lower than if you ask them if they trust their doctor. People tend to separate their personal experience from what they think is going on generally in society, and are perhaps too willing to dismiss their own evidence as “exceptions”. If they were favoring data over personal anecdote, that would be fine. But they are often favoring rumor, fearmongering, and sensationalism. Surveys like this, therefore, often reflect the public mood, rather than deeply held beliefs.

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Nov 14 2023

Hunter-Gatherers and Childcare

What is “natural” for humans? It’s often hard to say, and in my opinion this is a highly overused concept. Primarily this is because humans are adaptable – we adapt to our environment, our situation, and our culture. So it is “natural” for us not to have a natural state.

But this does not mean there are no insights to be gained by considering the evolutionary milieu in which our ancestors spent the vast majority of their existence. By rapidly changing our environment we may be pushing the limits of our adaptability. We also need to consider the difference between surviving and thriving. We may survive in the world we have created for ourselves, but pay some price. For those of us living in industrialized societies, it’s also difficult to appreciate how different our lives are from the vast majority of human history and societies. What is now “normal” for us is a recent anomaly.

We can apply this line of thinking to many aspects of our lives, but I want to consider childcare. A recent study looking at Mbendjele BaYaka Hunter-Gatherers in the Republic of Congo found a number of interesting thing regarding childcare. Young children received physical contact for the majority of their day. Overall they had near constant attention from a caretaker. About half of this attention came from someone other than the child’s mother or parents. Children benefitted form a network of caregivers of 10 or more people, and occasionally as many as 20 or more. Older children, teenagers, and adult relatives all contributed to childcare. These networks potentially have a number of implications.

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Nov 13 2023

Artificial Diamond Boom

The history of aluminum, and what is now happening in the artificial diamond market, may tell us something about a post-scarcity world. Aluminum is the most abundant metal in the Earth’s crust. However, it like to form with other elements and therefore it was very difficulty to purify the metal. In the 1800s methods were discovered for purifying aluminum, but they were slow and expensive, and hence aluminum was scarce and expensive – $16 per pound ($419 in today’s dollars), more expensive than gold at the time. Famously, Napoleon set before his most prestigious guests aluminum cutlery, instead of the less exciting gold cutlery. But then, in 1887, two men (both in their 20s), American Charles Martin Hall and Frenchman Paul Héroult independently discovered the same method for purifying aluminum from ore (usually bauxite). Within two years aluminum fell to $2 per pound, then pennies per pound. Now we make cans and foil out of it.

Will a similar thing happen to the diamond market? Diamonds, despite common belief, are not made from coal. They are created deep underground, 177-241 km, where pressures and temperatures are high. They are brought to the surface through volcanic eruptions, embedded in a mineral known as kimberlite. While natural diamonds are highly valued for their beauty and strength, there is a lot of controversy surrounding the mining of diamonds. The mining process is disruptive to the environment, and tends to involve a great deal of conflict and exploitation.

Further, the pricing of diamonds has been a bit controversial. Natural diamonds are generally considered to be overpriced by marketing and market manipulation. They are marketed as rare and valuable gems, but in reality they are quite plentiful. Marketing of diamonds as a “girls best friend” and for engagement rings also fed this image. Like everything, prices are generally about supply and demand, but demand is kept high through marketing while supply is generally kept secret in order to keep the price elevated. Gem-quality diamonds are also a luxury item, so their value is inherently subjective.

The first artificial diamond was created in 1954, using a method that involves high pressure and temperature. There is now also a newer method called chemical vapor deposition (CVD), which is cheaper and becoming more popular. India in particular has a booming industry in synthetic diamonds, and first to decrease the need for import, but now increasingly for export. The CVD method uses a gas chamber containing carbon, and may also contain other elements that affect the color of the diamond. The temperature and pressure are manipulated to cause the carbon to precipitate out of the gas, forming onto a seed diamond which can grow to large size. Many diamonds can be made at the same time using this method, which takes 1-2 weeks. Periodically graphite needs to be cleaned from the growing diamond.

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Nov 09 2023

Fossil Fuels – Reduce Demand or Supply?

This is a bit of a false choice – we can do both, or neither – but it is an important question and a somewhat of a dilemma. Is the optimal path to reductions and eventual elimination of fossil fuel burning through reduced demand or supply? There are some interesting tradeoffs either way, and no perfect answer.

To focus the question, it’s clear that we need to reduce demand as quickly as possible. This is not a question, and there is no dilemma here. Reducing demand is a win-win. We can do this in a number of ways. Switching from internal combustion to battery-electric vehicles is one way. Changing coal and gas power plants to wind, solar, nuclear, hydro, and geothermal is another. Increasing energy efficiency is also important – in homes, cars, and industry. Longer term we can also shift some of our societal patterns of behavior, creating more walkable cities, expanding public transport, and reducing waste.

Basically we need to electrify our technology, switch to green energy, and maximize efficiency. All of these are good things that will reduce pollution, create jobs, foster energy independence, and improve prosperity. Even if you are a climate change denier, you should still favor the green energy revolution (don’t let political propaganda dissuade you). If we were having this conversation in the 1990s, this would be all we need to talk about. How do we accelerate the switch over from fossil fuels by investing in R&D and providing strategic tax incentives? But it’s 2023, and time is basically up.

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Nov 07 2023

The Next Step in Space Travel

The European Space Agency (ESA) has announced they are developing their own commercial space capsule. This will be used initially for cargo, but then eventually for crew as well. They anticipate a maiden voyage in 2028.

I think this is a positive development. It seems we are slowing moving in the direction of increasing collaboration among international government and private space companies. This has existed from the beginning of the space program to some extent, but private companies are taking an increasing role, and more nations are getting involved as well. But what I want to talk about is what this space travel infrastructure will look like, and where that should be heading.

The history of the Apollo mission is a good place to start to frame the challenges of space travel. For Apollos NASA ultimately landed on a complex but workable solution. First you need a really big rocket, one able to life a large payload and give it enough acceleration to get into trans-lunar orbit – to get into orbit around the moon. This required a multi-stage rocket, the Saturn V. On top of that sat the lunar lander then the service module and then the command module (the capsule where the astronauts lived). After acceleration to the Moon was complete, the lunar module would detach and then flip around and dock with the top of the command module, so that astronauts could move between the two vehicles.

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Nov 06 2023

Will AI Make Work Redundant?

Artificial Intelligence (AI) is coming for your job. This, at least, is increasingly conventional wisdom, but I’m not so sure. In a recent interview, Elon Musk predicted that AI would “make paid work redundant.” I encountered the same opinion watching the latest season of Connections (yes, season 4 of Connections with James Burke), and I had the opportunity to interview James Burke about this (which will be on the next episode of the SGU). Many futurists are predicting a “post scarcity” or “post labor” world.

The idea, explored in many works of science fiction, is that a combination of AI and robotics will be able to do any labor required to run civilization. There would simply be no need for humans to engage in any sort of labor, freeing us for endless leisure. There is a lot of speculation and discussion about what such a world would look like. Will it be a paradise, where all our needs are met by attentive robots, and there is no poverty or want? Or will it be a dystopian nightmare, full of boredom, mindless distraction, a loss of any purpose, and a general atrophying of all human capability? Perhaps it will be both simultaneously. One vision has AI and robots taking care of all our physical needs, while we live our lives in virtual reality, gods of our own digital worlds.

It’s difficult to predict what a post-work world would look like. Partly this difficulty comes from not knowing the state of all other technology. Also, the people is that hypothetical future will not be us. They will exist generations from now, forged by social and technological changes we have not envisioned yet. Our current hand-wringing over what such a world will be like may seem quaint to them, like Medieval people trying to imagine our lives today.

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Oct 31 2023

Ghosts Are Not Real

It’s Halloween, so there are a lot of fluff pieces about ghosts and similar phenomena circulating in the media. There are some good skeptical pieces as well, which is always nice to see. For this piece I did not want to frame the headline as a question, which I think is gratuitous, especially when my regular readers know what answer I am going to give. The best current scientific evidence has a solid answer to this question – ghosts are not a real scientific phenomenon.

For most scientists the story pretty much ends there. Spending any more serious time on the issue is a waste, even an academic embarrassment. But for a scientific skeptic there are several real and interesting questions. Why do so many people believe in ghosts? What naturalistic phenomena are being mistaken for ghostly phenomena? What specific errors in critical thinking lead to the misinterpretation of experiences as evidence for ghosts? Is what ghost-hunters are doing science, and if not, why not?

The first question is mostly sociological. A recent survey finds that 41% of Americans believe in ghosts, and 20% believe they have had an encounter with a ghost. We know that there are some personality traits associated with belief in ghosts. Of the big five, openness to experience and sensation is the biggest predictor. Also, intuitive thinking style rather than analytical is associated with a greater belief in the paranormal in general, including ghosts.

The relationship between religious belief and paranormal belief, including ghosts, is complicated. About half of studies show the two go together, while the rest show that being religous reduces the chance of believing in the paranormal. It likely depends on the religion, the paranormal belief, and how questions are asked. Some religious preach that certain paranormal beliefs are evil, therefore creating a stigma against them.

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Oct 30 2023

Finding Common Ground on Democracy

How is American democracy doing, and what can we do to improve it, if necessary? This is clearly a question of political science, and I am not a political scientist, and this is not a political blog. But there are some basic principles of critical thinking that might apply, and the second word in “political science” is “science”. Further, while this is not a political blog, what that really means is that I endeavor to be non-partisan. I am not trying to advocate for any particular party or ideological group. But many of the issues I discuss have a political dimension, because most issues do. Global warming is a scientific question, but there are massive political consequences, for example.

So if you will indulge me, I want to apply some basic critical thinking principles to some pressing questions regarding our democracy. My goal is to see if we can find some common ground. This is something I frequently recommend in many contexts – if you are trying to convince someone that a particular belief of theirs is pseudoscience, a good place to start is to establish some common ground and then proceed from there. Otherwise you will likely be talking past each other.

Also, despite the fact that we seem to be having increasing partisan division in this country, my sense is that we still have much more common ground than may be apparent. The media and politicians both benefit from emphasizing division, conflict, and differences. Keeping everyone as outraged and agitated as possible maximizes clicks and votes. Both polling and personal experience, if you look beyond the surface level, also tell a story of common ground. Most common-sense positions are supported by large majorities. Most people want basically the same things – safety, prosperity, liberty, transparency and fairness. This is not to minimize the very real different value judgements that exist in society. This is why we need democracy to work out compromises.

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