Nov 10 2026
The Definition of “Biological Sex” – A Lesson for Skeptics
This article is the result of a rather long journey in science communication, and I think carries some important lessons for science communicators, skeptics, and anyone interested in this topic. What is the technical scientific definition of the term “biological sex”? I have to say I went into this discussion naively thinking that this question would be easy to resolve, and would serve as a good basis of common ground from which to discuss more complex related topics, specifically the trans phenomenon. This is a topic that divides popular skeptics and science communicators, and I am always fascinated and drawn to such controversies. They seem like fertile territory to deepen my understanding of complex topics, and hopefully to contribute to the conversation.
I soon learned that there were two fairly entrenched perspectives on this question. Jerry Coyne, Richard Dawkins and others were claiming that sex (whether an organism is male or female) is determined entirely by gamete size, with males having small gametes and females large gametes (a property known as anisogamy). I and others favor the multidimensional definition of biological sex – that it includes and is defined by the entire spectrum of biological sexual differences – chromosomes and genes, gonads, gametes, hormones, reproductive organs, genitals, and all secondary sexual characteristics. I admit and can see now that I assumed this was “the” scientific definition of sex. It was the definition I learned in medical school in the 1980s, and pretty much the only definition I encountered throughout my medical career. I was therefore somewhat surprised when I received push back from other science communicators that this was not “the” definition, even being accused of trying to change the definition to suit my needs, and of engaging in pseudoscience.
It seemed to me that these two schools of thought on sex were primarily determined by political ideology, and I still think that is playing a significant role. This is especially true among non-biologists, who mostly just accept the definition that fits their political opinions. This also allows for both sides to claim that science is on their side, and the other side is engaging in pseudoscience and allowing their politics to influence their scientific reasoning. This is pretty much where things sit – two entrenched sides largely talking past each other. This is not a good look for a group that identifies as skeptics and presumes to communicate science to the public.

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I am back from an almost three week trip to LA, Sydney and Christchurch. Sorry I did not have time to keep up with my blog over that period – in which we recorded four live SGU shows, produced three days of conference content, put on two stage shows, and hosted several other events. It was a tremendous amount of fun, but also a great deal of work. I am now jet-lagged and fighting off the remains of a viral infection I picked up along the way.
Engaging on social media to discuss pseudoscience can be exhausting, and make one weep for humanity. I have to keep reminding myself that what I am seeing is not necessarily representative. The loudest and most extreme voices tend to get amplified, and people don’t generally make videos just to say they agree with the mainstream view on something. There is massive selection bias. But still, to some extent social media does both reflect the culture and also influence it. So I like to not only address specific pieces of nonsense I find but also to look for patterns, patterns of claims and also of thought or narratives.
As human civilization spreads into every corner of the world, human and animal territories are butting up against each other more intensely. This often doesn’t end well for the animals. This is also causing evolutionary pressures that are adapting some species to living in close proximity to humans.
This is not really anything new, but it is taking on a new scope. The WSJ recently wrote about
Avi Loeb is at it again. He is the Harvard astrophysicist who first gained notoriety
One potentially positive outcome from the COVID pandemic is that it was a wakeup call – if there was any doubt previously about the fact that we all live in one giant interconnected world, it should not have survived the recent pandemic. This is particularly true when it comes to infectious disease. A bug that breaks out on the other side of the world can make its way to your country, your home, and cause havoc. It’s also not just about the spread of infectious organisms, but the breeding of these organisms.
It’s probably not a surprise that a blog author dedicated to critical thinking and neuroscience feels that misinformation is one of the most significant threats to society, but I really to think this. Misinformation (false, misleading, or erroneous information) and disinformation (deliberately misleading information) have the ability to cause a disconnect between the public and reality. In a democracy this severs the feedback loop between voters and their representatives. In an authoritarian government it a tool of control and repression. In either case citizens cannot freely choose their representatives. This is also the problem with extreme jerrymandering – in which politicians choose their voters rather than the other way around.


